George J Kontoghiorghes Selected Research

Generic Drugs

9/2013

A record number of fatalities in many categories of patients treated with deferasirox: loopholes in regulatory and marketing procedures undermine patient safety and misguide public funds?

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George J Kontoghiorghes Research Topics

Disease

36	Iron Overload 04/2024 - 01/2003
22	Thalassemia 08/2023 - 01/2006
17	Neoplasms (Cancer) 04/2024 - 01/2006
10	beta-Thalassemia (Cooley's Anemia) 11/2023 - 01/2009
9	Iron Deficiencies 04/2024 - 01/2005
9	Chronic Disease (Chronic Diseases) 11/2023 - 01/2006
5	Infections 04/2024 - 01/2002
5	Hemochromatosis (Bronze Diabetes) 08/2023 - 01/2005
4	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2024 - 03/2015
4	Friedreich Ataxia (Friedreich's Ataxia) 01/2020 - 01/2009
4	Heart Failure 12/2014 - 01/2008
4	Cardiomyopathies (Cardiomyopathy) 01/2014 - 01/2006
4	Agranulocytosis (Granulocytopenia) 07/2010 - 01/2003
3	Sickle Cell Anemia (Hemoglobin S Disease) 11/2023 - 01/2011
3	COVID-19 06/2022 - 07/2021
3	Communicable Diseases (Infectious Diseases) 01/2020 - 05/2013
2	Alzheimer Disease (Alzheimer's Disease) 08/2023 - 03/2015
2	Kidney Diseases (Kidney Disease) 01/2014 - 01/2009
2	Anemia 05/2013 - 01/2006
2	Renal Insufficiency (Renal Failure) 07/2010 - 05/2007
2	Heart Diseases (Heart Disease) 01/2006 - 11/2004
1	Inflammation (Inflammations) 04/2024
1	Diabetic Nephropathies (Diabetic Nephropathy) 04/2024
1	Drug-Related Side Effects and Adverse Reactions 11/2023
1	Disease Progression 08/2023
1	Hemoglobinopathies 08/2023
1	Carcinogenesis 08/2023
1	Parkinson Disease (Parkinson's Disease) 08/2023
1	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 03/2023
1	Hyperferritinemia 11/2022
1	Hypoxia (Hypoxemia) 11/2022
1	Neoplasm Metastasis (Metastasis) 11/2022
1	Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease) 01/2020
1	Splenomegaly 07/2017
1	Transfusion-Related Acute Lung Injury 01/2017
1	Central Nervous System Diseases (CNS Diseases) 03/2015
1	Gastrointestinal Hemorrhage (Hematochezia) 07/2010
1	Alopecia (Baldness) 07/2010
1	Exanthema (Rash) 07/2010
1	Anaphylaxis (Anaphylactic Shock) 07/2010
1	Mucormycosis 06/2010
1	Liver Failure 01/2008
1	Thrombosis (Thrombus) 01/2008
1	Cardiotoxicity 01/2008

Drug/Important Bio-Agent (IBA)

49	IronIBA 04/2024 - 01/2002
42	DeferiproneIBA 04/2024 - 01/2002
26	Deferoxamine (Desferal)FDA LinkGeneric 04/2024 - 01/2003
12	Chelating AgentsIBA 04/2024 - 01/2006
8	Free RadicalsIBA 08/2023 - 01/2008
7	Deferasirox FDA Link 04/2024 - 05/2007
7	Ferritins (Ferritin)IBA 11/2022 - 01/2006
4	maltolIBA 04/2024 - 11/2015
4	Proteins (Proteins, Gene)FDA Link 08/2023 - 01/2008
4	MetalsIBA 07/2023 - 01/2008
3	XenobioticsIBA 08/2023 - 01/2013
3	Ascorbic Acid (Vitamin C)FDA LinkGeneric 08/2023 - 07/2020
3	AntioxidantsIBA 07/2020 - 03/2016
2	Doxorubicin (Adriamycin)FDA LinkGeneric 08/2023 - 01/2008
2	Drug CombinationsIBA 11/2022 - 12/2021
2	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2011 - 01/2008
2	CopperIBA 01/2011 - 01/2008
2	IonsIBA 01/2011 - 01/2008
2	Transferrin (beta 2 Transferrin)IBA 01/2011 - 01/2006
2	ZincIBA 01/2008 - 01/2003
1	ferric maltolIBA 04/2024
1	Membrane LipidsIBA 08/2023
1	baricitinibIBA 12/2021
1	remdesivirIBA 12/2021
1	molnupiravirIBA 12/2021
1	tocilizumab (atlizumab)FDA Link 12/2021
1	Acetylcysteine (Siran)FDA LinkGeneric 12/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 12/2021
1	Ritonavir (Norvir)FDA Link 12/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2020
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2017
1	AntibodiesIBA 01/2017
1	MimosineIBA 11/2015
1	TropoloneIBA 11/2015
1	FrataxinIBA 12/2014
1	Generic DrugsIBA 09/2013
1	Hemoglobins (Hemoglobin)IBA 05/2013
1	SiderophoresIBA 06/2010
1	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2008
1	PlatinumIBA 01/2008
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 01/2008
1	DNA (Deoxyribonucleic Acid)IBA 01/2008
1	Coordination ComplexesIBA 01/2008
1	3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA 01/2008
1	4,4-difluororetinoic acidIBA 01/2008
1	Dexrazoxane (Zinecard)FDA LinkGeneric 01/2008

Therapy/Procedure

17	Therapeutics 11/2023 - 01/2002
12	Chelation Therapy (Therapy, Chelation) 04/2024 - 01/2006
2	Erythrocyte Transfusion 08/2023 - 01/2017
1	Stem Cell Transplantation 11/2023
1	Hematopoietic Stem Cell Transplantation 08/2023
1	Drug Therapy (Chemotherapy) 06/2022
1	Complementary Therapies (Alternative Medicine) 01/2014
1	Splenectomy 01/2013
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2009
1	Vascular Access Devices (Arterial Line) 01/2008